Japanese Clopidogrel Hyporesponsiveness in Patients with Coronary Artery Disease after Undergoing Stent Implantation (j-CHIPS Study).

Japanese Clopidogrel Hyporesponsiveness in Patients with Coronary Artery Disease after Undergoing Stent Implantation (j-CHIPS Study). - j-CHIPS Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000005375

Enrollment

1000

Registered

2011-04-05

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with coronary artery disease including ACS , who will be or has been taking clopidgrel (75 mg/day) and a low dose of aspirin. 2) Patients undergoing possible percutaneous coronary intervention (stent implantation). 3) Patients whose clinical laboratory test results are within the following ranges; Ht: 25-52% Platelet:119000-502000 /ul 4) Patients who will voluntarily give written informed consent before participating in this study

Exclusion criteria

Exclusion criteria: 1) Patients who will undergo an operation with bleeding. 2) Patients taking the following drugs; Warfarin, thrombolytics (tPA), etc. Other antiplatelet than Aspirin, Cilostazol, Clopidogrel (Dipyridamole, Sarpogrelate, Beraprost, etc.) 3) Patients of the taboo on the package of clopidogrel or aspirin.

Design outcomes

Primary

Measure	Time frame
Estimation of Cut-off value of clopidogrel low-responder using whole blood aggregometry	—

Secondary

Measure	Time frame
(1). to analyze the relationship between gene polymorphisms such as CYP2C19 or ABCB-1 and the responsivness to clopidogrel, (2). to analyze the patients characteristics associated with the responsiveness to Clopidgrel, and (3). to estimate the cut-off value of bleeding events (TIMI Classification: Major or Minor bleeding)	—

Countries

Japan

Contacts

Public ContactYuki Nishimura

Mie University Hospital Clinical Research Support Center

ynishimura@clin.medic.mie-u.ac.jp059-231-5278

Outcome results