Parkinson disease
Conditions
Interventions
None listed
Sponsors
Nihon University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Advanced idiopathic PD is diagnosed in all patients and refer to us by neurologists with an intimate knowledge of the pharmacological treatment of PD. Our surgical indication criteria for STN stimulation is clinically diagnosed advanced idiopathic PD which demonstrate evidence of a good response to levodopa, and a Hoehn and Yahr staging that is within the range of stages III-V during the off-period and stage III or less in the best on-condition despite treatment with optimal pharmacological therapies. by our group
Exclusion criteria
Exclusion criteria: Patients with major depression or cognitive dysfunction (Mini-Mental Status Examination score < 23) are excluded as candidates for surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Data are collected from this cohort prospectively. All patients describe the severity of their pain according to a visual analogue scale (VAS; 0-10.0 points) preoperatively and at 2 weeks, 6 and 12 months postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS) is scored during the on-period and off-period with sustaining anti-parkinsonian agents. The levodopa-induced dyskinesias (LID) are categorized into three groups; off-period, diphasic, and on-period dyskinesia. The dyskinesia severity rating scale is employed to evaluate the severity of each of LID, scoring the dyskinesia in 6 body parts (neck, trunk, and each of the 4 extremities) on a 5-point scale (ranging from 0 to 4; e.g. 0=absent, 4=severe). All patients are also assessed for their mood using the Hamilton depression scale and their cognitive function by using Mini-Mental Status Examinations. | — |
Countries
Japan
Contacts
Public ContactHideki Oshima
Nihon University School of Medicine Neurological Surgery
Outcome results
None listed