Gynecologic malignancy
Conditions
Interventions
Participants allocated to the combined enoxaparin/IPC group will receive intermittent pneumatic compression starting just before the surgery until they receive their first injection of enoxaparin (9:3
Sponsors
The Jikei University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Patients more than or equal to 40 years old Patients more than or equal to 40 kg Patients receiving a surgery* for gynecologic malignancy Patients whose informed consent is obtained *: Surgery is defined as an abdominal surgery or other surgeries which take more than 45 minutes.
Exclusion criteria
Exclusion criteria: Patients with venous thromboembolism Patients allergic to enoxaparin and/or heparin/heparin derivatives Patients with active bleeding (intracranial hemorrhage, retroperitoneal hemorrhage, and/or hemorrhage from other major organs) or at higher risk of bleeding (hemostatic disorder, gastric ulcer, recent ischemic stroke, uncontrollable hypertension, diabetic retinopathy, and/or recent brain or eye surgery) Patients with acute bacterial endocarditis Patients with severe renal dysfunction (CCr < 50ml/min = eGFR < 40ml/min/1.73m2) Patients with severe liver dysfunction Patients with history of heparin induced thrombocytopenia (HIT) Patients with history of venous thromboembolism and/or thrombotic tendency Patients taking anticoagulants, platelet aggregation inhibitors, salicylic acid derivatives, and/or thrombolytic drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic/asymptomatic venous thromboembolism (deep venous thrombosis and pulmonary thromboembolism) | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinically apparent bleeding events developed after 9:30 PM, postoperative day 1 Thrombocytopenia developed after 9:30 PM, postoperative day 1 | — |
Countries
Japan
Contacts
Public ContactChie Nagata
The Jikei University School of Medicine Department of Obstetrics and Gynecology
Outcome results
None listed