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A prospective randomized controlled trial of two different for hepatic transection: cavitron ultrasonic surgical aspirator with irrigating bipolar electrocautery versus cavitron ultrasonic surgical aspirator with radiofrequency bipolar sealer

A prospective randomized controlled trial of two different for hepatic transection: cavitron ultrasonic surgical aspirator with irrigating bipolar electrocautery versus cavitron ultrasonic surgical aspirator with radiofrequency bipolar sealer - CUSA with bipolar cautery vs. CUSA with radiofrequency bipolar sealer for hepatic transaction

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000005325
Enrollment
100
Registered
2011-04-01
Start date
2011-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A case who need to hepatic resection for primary hepatocellular carcinoma, intrahepatic cholangiocarcinoma, gallbladder cancer, hilar cholangiocellular carcinoma, metastatic liver cancer, and transplantational donor).

Interventions

CUSA with irrigating bipolar electrocautery CUSA with a radiofrequency bipolar sealer [TissuLink &amp

Sponsors

Department of Surgery, Kansai Medical Univedrsity
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)no preceded treatment 2)no extrahepatic lesion or major vascular invasion 3)performance status 0-2 4) bone marrow function and hepatic/renal functions are well maintained a)White blood cell count: 2000- 10000/mm3 b)Platelet count of 50000/mm3 or more c)Hemoglobin of 8.0g/dL or more d)Serum total bilirubin of 2.0mg/dL or less e)Prothronbin time of 50% or more f)Serum creatinine of 1.5mg/dL or less g)Blood urea nitrogen of 35mg/dL or less

Exclusion criteria

Exclusion criteria: 1) Double cancer or history of other malignancy within 5 years after diagnosis 2) History of myocardial infarction or unstable angina within 6 months prior to registration 3) Patient with interstitial pneumonia, pneumofibrosis, or severe lung emphysema 4) Patient who cannot undergo enhanced CT scan due to some reason such as allergy for iodized contrast media or renal dysfunction 5) Patient with psychiatric disorder or symptom 6) Pregnant patient or patient with possibility to be pregnant

Design outcomes

Primary

MeasureTime frame
Blood loss during parenchymal transaction and speed of transaction

Secondary

MeasureTime frame
The degree of postoperative liver injury and morbidity

Countries

Japan

Contacts

Public ContactMasaki Kaibori

Kansai Medical University Department of Surgery

kaibori@hirakata.kmu.ac.jp072-804-0101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026