Diagnosis of Early LIver CAncer Through EOB-MRI Study

Diagnosis of Early LIver CAncer Through EOB-MRI Study - DELICATE Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000005323

Enrollment

400

Registered

2011-03-28

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HCC borderline lesion

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.20 Years and older. 2.Patient who have HCV, HBV and non-virus related chronic liver disease without alcohol related choronic liver disease. 3.Nodules that diagnosed non-hyper vascular at least 2 imaging modalities. 4. Patiens who have non-hyper tumors and classical HCCs, but classical HCCs can be treated curatively. 5.Patient who have a treatment career of HCC once in the past, but received a curative treatment. 6.Patients who can receve a regular imaging examinations. 7.Written Informed Consent must be obtained. 8.ECOG Performance status of 0 or 1.

Exclusion criteria

Exclusion criteria: 1.Known allergy to the investigational agent or any agent given in association with this trial. 2.Patiens who have severe liver damage. 3.Asthma patients 4.Patient who has metal in the body 5.patient having the active digestive organs bleeding.It is a case with the hospitalization career within the past one month. 6.A patient of the minority. 7.Pregnant or breast-feeding patients. 8.ECOG Performance status of more than 2. 9. Any condition that could jeopardize the safety of the patient or their compliance in the study

Design outcomes

Primary

Measure	Time frame
Evaluate a dediferential rate of non-hypervascular tumors in natural course	—

Secondary

Measure	Time frame
1.Evaluate a dedifential rate of each nodule wheter the result of the image of post-vascular phase of the tumor affect the dedifential rate. 2.Compare the hepatobiliary phase images of EOB-MRI with histological results of tumors. 3.Compare the hepatobiliary phase images of EOB-MRI with expression of transporters of tumors. 4.Compare the dediferention rate of tumors between HBV and HCV patients. 5.Histological evaluation of tumors that can detect on ultrasonography with magnetic navigation system while EOB-MRI failed to detect. 6.Histological evaluation of tumors that can detect on EOB-MRI while fundamental B-mode ultrasonography failed to detect. We use ultrasonography with magnetic navigation system to acquire specimens.	—

Measure

Time frame

1.Evaluate a dedifential rate of each nodule wheter the result of the image of post-vascular phase of the tumor affect the dedifential rate. 2.Compare the hepatobiliary phase images of EOB-MRI with histological results of tumors. 3.Compare the hepatobiliary phase images of EOB-MRI with expression of transporters of tumors. 4.Compare the dediferention rate of tumors between HBV and HCV patients. 5.Histological evaluation of tumors that can detect on ultrasonography with magnetic navigation system while EOB-MRI failed to detect. 6.Histological evaluation of tumors that can detect on EOB-MRI while fundamental B-mode ultrasonography failed to detect. We use ultrasonography with magnetic navigation system to acquire specimens.

—

Countries

Japan

Contacts

Public ContactTatsuo Inoue

Kinki University Faculty of Medicine Department of Gastroenterology and Hepatology

t-inoue@med.kindai.ac.jp

Outcome results