Periodontal diseases
Conditions
Interventions
300mg OLE intake group Take 2 tablets of 100mg OLE 3 times a day before meal
600mg OLE intake group Take 2 tablets of 200mg OLE 3 times a day before meal
Placebo group Take 2 placebo tablet
Sponsors
Department of Preventive Dentistry, Osaka University Graduate School of Dentistry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Those who have average PPD between 2mm and 4mm Those who have average GI greater than 0 Age from 20 to 49 Those who have at least 20 teeth
Exclusion criteria
Exclusion criteria: Those who took periodontal surgical therapy within 6 months Those who are pregnant or lactating Those who have a history of systematic diseases Those who took antibiotics within 3 months Those who took anti-inflammatory drugs within 2 weeks Those who have unrestored caries Those who smoke within 6 months Those who participate in other clinical trial Those who are judged not eligible for the study subjects by their investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing pocket depth(PPD), Gingival index(GI), Bleeding on probing(BOP) | — |
Secondary
| Measure | Time frame |
|---|---|
| Remaining teeth, Clinical attachment level, Plaque index, Cytokines in GCF | — |
Countries
Japan
Contacts
Public ContactHideki Nagata
Osaka University Graduate School of Dentistry Department of Preventive Dentistry
Outcome results
None listed