Direct Renin Inhibitor decreases central systolic blood pressure.

Direct Renin Inhibitor decreases central systolic blood pressure. - Direct Renin Inhibitor decreases central systolic blood pressure.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005281

Enrollment

Registered

2011-03-23

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertensive patients

Interventions

Essential hypertension who showed a systolic blood pressure of 140 mmHg or more after 12-week DRI administration at 150 mg/day. We employed the PROBE method, the subjects were assigned to receive an i

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Essential hypertension who showed a systolic blood pressure of 140 mmHg or more after 12-week DRI administration at 150 mg/day.

Exclusion criteria

Exclusion criteria: 1) Secondary hypertension patients 2) Bilateral or unilateral renal arterial stenosis 3) Severe renal dysfunction requiring hemodialysis or peritoneal dialysis 4) Severe hepatopathy/nephropathy or heart disease that may affect the evaluation of drug safety 5) Patients who are deemed to be inappropriate by the investigator or sub-investigators

Design outcomes

Primary

Measure	Time frame
Central blood pressure	—

Secondary

Measure	Time frame
The blood pressure, the aortic PWV, microalbuminuria, and high-sensitivity C-reactive protein (CRP) level.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026