Transcranial magnetic stimulation (TMS) in the treatment of nicotine dependence: A single-blind, randomized, sham-controlled crossover trial

Transcranial magnetic stimulation (TMS) in the treatment of nicotine dependence: A single-blind, randomized, sham-controlled crossover trial - Transcranial magnetic stimulation (TMS) in the treatment of nicotine dependence

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005279

Enrollment

Registered

2011-04-01

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nicotine dependence

Interventions

TMS will be applied in the left and right prefrontal cortex. Left Sham, Washout (over 2 days), Left TMS Left TMS, Washout (over 2 days), Left Sham Right Sham, Washout (over 2 days), Right TMS Right

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with DSM-IV-TR of nicotine dependence 2) Age of patients between 20-65 years 3) Smoking at least 20 cigarettes per day

Exclusion criteria

Exclusion criteria: 1) Taking psychiatric medications 2) Schizophrenia, personality disorders, history of neurological disorders or organic brain disorders 3) History of convulsive disorders 4) Drug or alcohol abuse/dependence 5) Implanted electronic devices/magnetic material 6) Severe physical diseases, endocrine diseases

Design outcomes

Primary

Measure	Time frame
Fagerstrome Test for Nicotine Dependence (FTND); Tobacco Dependence Screener (TDS); Visual analogue scale for nicotine craving (VAS); Visual analogue scale for mood (VAS)	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026