Hypertension
Conditions
Interventions
candesartan12mg
candesartan 8mg + hydrochroltiazide 6.25mg
Sponsors
Juntendo University School of Medicine, Department of Cardiovascular Medicine
Juntendo University Shizuoka Hospital Juntendo University Urayasu Hospital Juntendo University Nerima Hospital Koto Hospital Tobu Chiiki Hospital Koshigaya Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age=>20 years 2. Hypertensive patients who did not achieve the target blood pressure of JHS 2009 criteria 3. Hypertensive patients treated with 8 mg/day of candesartan for more than 2 months
Exclusion criteria
Exclusion criteria: 1. Patients with a history of hypersensitivity to the study drugs 2. Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 3. Patients with chronic renal failure (serum creatinine => 2.0 mg/dL) 4. Patients with anuria or on dialysis 5. Patients with acute renal failure 6. Patients whose levels of sodium and/or potassium are obviously low 7. Patients who are pregnant, possibly pregnant, or lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The achievement rate of blood pressure targets measured at home (home BP) and at the outpatient department according to the Japanese Society of Hypertension (JSH) 2009 criteria 2. Changes in the levels of cardio-renal associated markers, inflammatory markers and glucose metabolism | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in 24-h ambulatory blood pressure, lipids, microalbuminuria, uric acid, and serum potassium | — |
Countries
Japan
Contacts
Public ContactKazunoir Shimada
Juntendo University School of Medicine Department of Cardiovascular Medicine
Outcome results
None listed