infertile women, endometriosis
Conditions
Interventions
L group: Long protocol group (control group: without DNG) Gonadotropin-releasing hormone agonist (GnRHa, 900 micro g/day) is given from the mid-luteal phase in the previous cycle to the ovulation ind
Sponsors
Department of Obstetrics and Gynecology, Yamaguchi University Graduate School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Endometriosis-associated infertile women who undergo IVF-ET program. 1) woman who has endometrioid cyst (chocolate cyst) (cyst diameter < 4cm) diagnosed by imaging. 2) woman who give written informed consent before entry into this study.
Exclusion criteria
Exclusion criteria: 1) patients who had GnRHa ultra long protocol last 6th month 2) patients who had DNG and/or EP treatment or GnRHa treatment ( > 3 month)for endometriosis 3) patients who has undiagnostic genital bleeding 4) a pregnant woman 5) patients who has estrogen dependence tumor (breast cancer, endometrial cancer) 6) patients who has history of breast cancer 7) patients who has Thrombophlebitis and/or Pulmonary thrombosis, or history of these disease. 8) patients who has the thromboembolism disease of the artery (coronary heart disease, Cerebral apoplexy) or history of these disease 9) patients who has liver dysfunction, or liver disease 10) patients who has Hypersensitivity to DNG, GnRHa, EP, FSH, HMG, HCG 11) patients who is judged to be inappropriate for this study by the doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) total amount of FSH/HMG 2) number of growing follicle (<15mm) and mature follicle (<18mm), number of oocyte retrieved 3) fertilization rate, implantation rate 4) serum concentration of estradiol and progesterone (on the day hCG injection) 5) intrafollicular concentration of cytokines (interleukin-6, tumor necrosis factor alpha), oxidative stress markers (8-htdroxy-2'-deoxyguanosine, hexanoyl-lysine), Cu,Zn-superoxide dismutase 6) serum concentration of CA125 7) concentration of interleukin-6 and tumor necrosis factor alpha in peritoneal fluids | — |
Countries
Japan
Contacts
Public ContactHiroshi Tamura
Yamaguchi University Graduate School of Medicine Obstetrics&Gynecology
Outcome results
None listed