small unruptured cerebral aneurysm
Conditions
Interventions
atorvastatin group: atorvastatin is administered at a daily dose of 10 mg for 3 years.
non-administration group
Sponsors
Department of neurosurgery, faculty of medicine, Kyoto university
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) small unruptured cerebral saccular aneurysms (more than 3 mm and under 5 mm) diagnosed within 3 years from the date of registration. 2) aneurysms located in the circle of Willis or distal to the circle of Willis. 3) aneurysms are to be followed by MRA without surgical intervention after registration. 4) informed consent was obtained from the patient. 5) age of the patient is more than 20 and under 70 at the date of registration. 6) modified Rankin scale: 0~2 7) patients are capable of visiting out-patient clinic
Exclusion criteria
Exclusion criteria: 1) comorbid untreated unruptured aneurysms larger than 5mm 2) within 6 months after direct/endovascular surgery for comorbid aneurysms 3) when comorbid surgically treated aneurysm is a giant aneurysm 4) patients with hyperlipidemia who need medical treatment 5) patients receiving fenofibrate 6) atorvastatin hypersensitivity 7) patients receiving anticoagulant or antithrombotic 8) patients with a history of intracerebral hemorrhage 9) patients with a history of cerebral infarct within 6 months 10) comorbid arteriovenous malformation 11) comorbid moyamoya disease 12) patients with severe hepatic dysfunction 13) alcohol intoxication 14) patient during pregnancy or lactation 15) medically uncontrolled hypertension 16) patient under treatment for malignancy 17) cardiac failure, myocardial infarction or unstable angina within 6 months 18) renal failure 19) respiratory failure 20) patients disqualified by the physician-in-charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)aneurysm enlargement over 0.5 mm 2)aneurysm morphological change (e.g., bleb formation) 3)rupture | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiovascular events | — |
Countries
Japan
Contacts
Public ContactKazuimichi Yoshida
Kyoto university, faculty of medicine neurosurgery
Outcome results
None listed