Poorly controlled type 2 diabetic patients.
Conditions
Interventions
This study is a prospective randomized control trial. The entry period of this study is three years. Study subjects are poorly controlled type 2 diabetic patients. These patients are randomly assigned
Sponsors
Graduate School of Medicine, Tohoku University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The subjects enrolled in the present study are poorly glycemic controlled out-patients with type 2 diabetes mellitus, who fulfill the following criteria; 1) poorly glycemic controlled defined as the HbA1c of more than 6.0%. 2) The medicine is not changed within the last three months, and the change of the medicine is not scheduled for the examination period (three months). 3) Serum creatinine is less than 2.5 mg/dl. 4) The participation agreement of this study is obtained.
Exclusion criteria
Exclusion criteria: 1) The participation agreement of this study is not obtained. 2) To have other serious and active diseases such as severe hypertension, liver dysfunction, cardiovascular disease and so on. 3) Corresponding to the serum creatinine level > 2.5 mg/dl, or receiving continuous dialysis). 4) Woman who has pregnancy or possibility of pregnancy and suckling. 5) The patient that corresponds to contraindication of siutagliptin treatment. 6) Severe hyperglycemic subjects (HbA1c>10%). (It is necessary to do the insulin treatment.) 7) Patient from whom physician in charge of treatment judged this study participation to be improper.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| percent change of plasma methylglyoxal level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent changes in blood pressure, HbA1c, the urinary excretions of albumin, MCP-1, 8-OHdG and AGT. | — |
Countries
Japan
Contacts
Public ContactSusumu Ogawa
Tohoku University Hospital Division of Nephrology, Endocrinology and Hypertension
Outcome results
None listed