The study evaluating the effects of pravastatin and atrovastatin on regulation of small GTP-binding proteins in human

The study evaluating the effects of pravastatin and atrovastatin on regulation of small GTP-binding proteins in human - SMG-Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005105

Enrollment

20

Registered

2011-02-21

Start date

2011-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atherosclerotic cardiovascular diseases

Interventions

Atrovastatin(20mg/day) Pravastatin(20mg/day)

Sponsors

Department of cardiovascular medicine, Tohoku university graduate school of medicine

Lead Sponsor

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy individual

Exclusion criteria

Exclusion criteria: 1) Pregnant or possibly pregnant individuals 2) Current smorker or history of smoking

Design outcomes

Primary

Measure	Time frame
Expression of SmgGDS in human leucocytes	—

Secondary

Measure	Time frame
1)Expressions and activities of small GTP binding proteins 2)Serum levels of total cholesterol, LDL cholesterol, triglyceride,MDA-LDL, and RLP-C 3) Bio-markers for oxidant stress (8-isoprostane and PTX-3) 4) Urinary cyclic GMP, 8-isoprostane, and 8-OHdG	—

Countries

Japan

Contacts

Public ContactKotaro Nochioka

Tohoku university graduate school of medicine Department of cardiovascular medicine

nochioka@cardio.med.tohoku.ac.jp022-717-7153

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026