Steroid sensitive nephrotic syndrome in children
Conditions
Interventions
A: Standard Prednisolone therapy
B: Standard Prednisolone therapy + High-dose Mizoribine
Sponsors
Japanese Study Group of Kidney Disease in Children
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)The initial episode of idiopathic nephrotic syndrome (2)Treated with PSL therapy based on the International study of kidney disease and Diagnosed first relapse within 6 months when remission at first episode was confirmed (3)Aged two years under 11 years (4)Diagnosis of steroid sensitive has been performed within the third week after the onset of PSL therapy against first relapse (5)Patient will be able to go to hospital during therapy (6)Written informed consent from the patients' parents or legal guardians
Exclusion criteria
Exclusion criteria: (1)Other renal nephrotic syndrome(persistent hematuria) (2)History of Henoch-Sch&ouml;nlein nephritis, systemic lupus erythematosus or secondary nephrotic syndrome (3)History of steroid resistant (4)History of immunosuppressants administration against nephrotic syndrome (5)Uncontrollable hypertension (6)Renal dysfunction(creatinine clearance < 90 mL/min) (7)Severe liver dysfunction (8)Patients enrolling another clinical trials at the first relapse (9)Judged inappropriate for this study by the physicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to frequent relapse | — |
Countries
Japan
Contacts
Public ContactYuko Shima
Wakayama Medical University Department of Pediatrics
Outcome results
None listed