local advanced non-small cell lung cancer
Conditions
Interventions
pemetrexed + radiation therapy
Sponsors
Kinki-Chuo Chest Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1 Local advanced stage ,Stage III 2 unable to perform surgery and able to radiation therapy, V20 < 35% 3 Histlogocally and/or cytologically proven NSCLC 4 Age: 71 years old or more 5 PS, ECOG scale: 0 to 2 6 Adequate organ function ANC >2000/mm3, Hb >9.0g/dl T-Bil <1.5mg/dl CCr >45ml/min Cr < Normal upper limit AST/ALT < 2.5 x Normal Upper limit PaO2 room air > 70mmHg 7 Written informed concent 8 over 3 months life time expectancy 9 Have the assessment lesion
Exclusion criteria
Exclusion criteria: 1 Double cancer 2 Severe hypertension 3 Have the anamnesis of heart failure or cardiac infarction 4 Uncontrolled diabetes 5 Do not adhibit the Vitamin B12 and follic acid 6 Have the interstitial change on chest X-ray or chest CT 7 Have the bacterial infection 8 Have the disturbance patients 9 Attending judge the patients not to enregister because of safety
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Phase I: recommended dose of pemetrexeds Phase II: response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Phase I: progression free survival overall survival response rate Phase II: progression free survival overall survival safety | — |
Countries
Japan
Contacts
Public ContactAkihiro Tamiya
Kinki-Chuo Chest Medical Center Thoracic Oncology
Outcome results
None listed