Periodontitis (intrabony defect with probing depths more than 4 mm)
Conditions
Interventions
Autologous periodontal ligament cell sheets is transplanted to the denuded root surface during the modified Widman flap procedure.
Sponsors
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Patients having intrabony defects with probing depths more than 4 mm after initial therapy. Radiographic evidence of intrabony defects had to exist. (2)All patients gave written informed consent. (3)Patients having a redundant tooth which contains healthy periodontal tissues.
Exclusion criteria
Exclusion criteria: 1) relevant medical conditions contraindicating surgical interventions (e.g., diabetes mellitus, cardiovascular, kidney, liver, or lung disease, or compromised immune system. 2) pregnancy or lactation. 3) tobacco smoking (more than 11 cigarettes a day)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is to evaluate the safety of autologous transplantation of periodontal ligament cell sheets. | — |
Secondary
| Measure | Time frame |
|---|---|
| We also evaluate the clinical efficacy of autologous transplantation of periodontal ligament cell sheets. | — |
Countries
Japan
Contacts
Public ContactTakanori Iwata
Tokyo Women's Medical University Department of Oral and Maxillofacial Surgery
Outcome results
None listed