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Intravitreal bevacizumab injection versus subtreshold grid laser treatment for recurrent macular edema secondary to branch retinal vein occlusion

Intravitreal bevacizumab injection versus subtreshold grid laser treatment for recurrent macular edema secondary to branch retinal vein occlusion - Intravitreal bevacizumab injection versus subtreshold grid laser treatment for recurrent macular edema secondary to branch retinal vein occlusion

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000005014
Enrollment
22
Registered
2011-02-07
Start date
2009-02-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Recurrent macular edema secondary to branch retinal vein occlusion

Interventions

Subthreshold grid laser treatment intravitreal bevacizumab injections

Sponsors

Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. patients affected by macular edema secondary to BRVO already undergone conventional grid laser photocoagulation 2. best corrected visual acuity (BCVA) between 20/400 and of 20/40 3. Central thickness greater than 250 microns on OCT

Exclusion criteria

Exclusion criteria: 1. detection of retinal capillary non-perfusion more than 5 disc diameter on fluorescein angiography coexistence of any other chorioretinal disease 2. presence of cataract or any other ocular conditions able to confound the results 3. uncontrolled systemic hypertension 4. peripheral vascular disease and history of thromboembolism, ischemic heart disease or stroke.

Design outcomes

Primary

MeasureTime frame
The reduction in the mean central retinal thickness evaluate on optical coherence tomography scan.

Secondary

MeasureTime frame
The mean best-corrected visual acuity changes over the follow-up and the proportion of eyes that gained at least 15 letters (approximately 3 lines) at the 12-month examination.

Countries

Europe

Contacts

Public ContactProf. Francesco Bandello

University Vita-Salute, Scientific Institute San Raffaele Department of Ophthalmology

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026