The association between lifestyle factors and DNA methylation levels in gastric mucosa of participants in cancer screening

The association between lifestyle factors and DNA methylation levels in gastric mucosa of participants in cancer screening - Lifestyle factors and DNA methylation levels in gastric mucosa

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000005005

Enrollment

300

Registered

2011-02-02

Start date

2009-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Interventions

Treatment to eradicate Helicobacter pylori in infected participants: 7-day course of lansoprazole, clarithromycin, and amoxicillin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Examinees who 1) underwent upper gastrointestinal endoscopy as part of the cancer screening program provided by the Research Center for Cancer Prevention and Screening of the National Cancer Center and 2) gave written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: 1) History of treatment for Helicobacter pylori infection, 2) use of nonsteroidal anti-inflammatory drugs during previous 30 days, 3) upper gastrointestinal endoscopy during previous 1 year, 4) >=10% weight loss during previous 3 months, 5) history of gastric cancer, 6) history of gastrectomy, antireflux procedure, or vagotomy, 7) pregnancy

Design outcomes

Primary

Measure	Time frame
DNA methylation levels in gastric mucosa	—

Countries

Japan

Contacts

Public ContactTaichi Shimazu

Research Center for Cancer Prevention and Screening, National Cancer Center Epidemiology and Prevention Group

kenshin@ncc.go.jp03-3542-2511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026