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The effect of sitagliptin on pancreatic beta-cell protection for the type 2 diabetic patients treated with sulfonylurea : a prospective randomized, multicenter, open-label, comparative study.

The effect of sitagliptin on pancreatic beta-cell protection for the type 2 diabetic patients treated with sulfonylurea : a prospective randomized, multicenter, open-label, comparative study. - Sitagliptin vs. Step-up SU Study for the protection of beta-cell in Shinshu (SSSSS)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000004985
Enrollment
240
Registered
2011-02-01
Start date
2011-02-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 Diabetes Mellitus

Interventions

Titration of Glimepiride Add-on Stagliptin

Sponsors

Shinshu University Graduate School, Devision of Medicine, Department of Aging Medicine and Geriatrics
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with type 2 diabetes who is treated by Glimepiride less than 2mg/day for more than 4 weeks. 2. Age >= 20 years, <75 years, Male and Female 3. HbA1c >= 7.0%, <9.0% JDS

Exclusion criteria

Exclusion criteria: 1. Patients with renal failure. 2. Patients with cancer. 3. Patients with nephropathy more than 3b period. 4. Patients with preproliferative or proliferative retinopathy. 5. Other patients determined to be inappropriate by physician.

Design outcomes

Primary

MeasureTime frame
Pancreatic beta-cell protection ( Serum C peptide, Intact proinsulin/Insulin ratio )—

Secondary

MeasureTime frame
HbA1c, fasting plasma glucose, HOMA-beta, Insulinogenic Index, Total cholesterol, triglyceride, HDL cholesterol, BNP, cystatin C, urinary albumin/creatinin ratio, body weight, adherence—

Countries

Japan

Contacts

Public ContactTeiji Takeda

Shinshu University Graduate School, Devision of Medicine Department of Aging Medicine and Geriatrics

0263-37-2686

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026