Feasibility trial of neoadjuvant chemoradiotherapy in patients with locally advanced gastric cancer

Feasibility trial of neoadjuvant chemoradiotherapy in patients with locally advanced gastric cancer - Feasibility trial of neoadjuvant chemoradiotherapy in patients with locally advanced gastric cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000004960

Enrollment

Registered

2011-01-26

Start date

2005-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) histologically proven gastric adenocarcinoma 2) tumor invasion of adjacent structures (T4) and/or tumors with bulky nodal metastases 3) no metastases outside of Group 2 lymph nodes, no peritoneal metastasis, no liver metastasis and no other distant metastasis 4) PS0 - PS2 5) no prior radiation therapy 6) sufficient organ function 7) written informed consent

Exclusion criteria

Exclusion criteria: 1) a synchronous or previously active malignancy 2) insufficient oral intake 3) a history of severe allergy 4) watery diarrhea 5) severe co-morbidities 6) requiring therapy for pericardial effusion or pleural effusion 7) contraindications to S-1 or radiotherapy

Design outcomes

Primary

Measure	Time frame
feasibility safety	—

Secondary

Measure	Time frame
pathological response rate overall survival.	—

Countries

Japan

Contacts

Public ContactTatsushi Inoue

Surgery, School of Medicine, Kagawa University Department of Gastroenterological Surgery

087-891-2111

Outcome results