The comparison of the effect of calcium channel blockers on blood pressure lowering and presevation of renal function in refractory hypertensive patients

The comparison of the effect of calcium channel blockers on blood pressure lowering and presevation of renal function in refractory hypertensive patients - The comparison of the effect of CCBs on BP and renal function in refractory hypertensive patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004909

Enrollment

Registered

2011-02-01

Start date

2011-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

refractory hypertension

Interventions

Nifedipine CR 40mg (6 months), then Amlodipine 5mg (6 months) Amlodipine 5mg (6 months), then Nifedipine CR 40mg (6 months)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: refractory hypertensive patients with 1. office blood pressure>=140/90 mmHg or more 2. DM, CKD, MI patients: BP>=130/80 mmHg or more (*patients with proteinuria BP>=1g/gCr: 125/75 mmHg) 3. CVA patients: BP>=140/90 mmHg or more

Exclusion criteria

Exclusion criteria: 1. taking Nifedipine or Amlodipine 2. history of hypersensitivity to Amlodipine and/or Nifedipine 3. secondary hypertension 4. pregnant, becoming pregnant 5. cardiogenic shock 6. planning dialysis within 1 year 7. regarded as inadequate for enrollment by investigator

Design outcomes

Primary

Measure	Time frame
Blood pressure lowering between 2 remedies (delta SBP and delta DBP after 3, 6, and 12 month)	—

Secondary

Measure	Time frame
1)achievement rate of target blood pressure 2)change in renal dysfunction 3)change in hs-CRP 4)change in endocrine system	—

Countries

Japan

Contacts

Public ContactTakashi Yasuda

St. Marianna University School of Medicine Nephrology and Hypertension

044-977-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026