Clinical trial of effects of Low-intensity Pulsed Ultrasound (LIPUS) on angiogenesis and safety in patients with critical limb ischemia

Clinical trial of effects of Low-intensity Pulsed Ultrasound (LIPUS) on angiogenesis and safety in patients with critical limb ischemia - LIPUS study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004901

Enrollment

50

Registered

2011-01-19

Start date

2010-09-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with arteriosclerotic peripheral arterial disease, Buerger&#39

Interventions

LIPUS treatment LIPUS untreated (control)

Sponsors

Hiroshima University Hospital

Lead Sponsor

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with critical limb ischemia

Exclusion criteria

Exclusion criteria: Patients with cancer Patients with stroke and/or myocardial infarction within 12 weeks of the prior to study Patients with heart failure (&#8805;NYHA4)

Design outcomes

Primary

Measure	Time frame
flow-mediated vasodilation (FMD)	—

Secondary

Measure	Time frame
ABPI, PWV Clinical symptoms and visual analog score Safty	—

Countries

Japan

Contacts

Public ContactYukihito Higashi

Hiroshima university Hospital Division of Regenerative Medicine

yhigashi@hiroshima-u.ac.jp082-257-5122

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026