Lumbar spinal stenosis
Conditions
Interventions
15ug/day Limaprost arfadex for 8 weeks
200mg/day Celecoxib for 8 weeks
Sponsors
University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare Federation
Mito Kyodo Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Above seven point of the score for a diagnostic support tool for lumbar spinal stenosis 2.Radiologic diagnosis of lumbar spinal stenosis 3.Capable of giving informed consent
Exclusion criteria
Exclusion criteria: 1.Congenital lumbar spinal stenosis 2.Operation for lumbar spinal stenosis before three months 3.Indication for operation 4.Taking NSAIDs, Limaprost and Steroids before a week 5.Exclusion criteria a)ASO and below 0.9 of ABI b)Cerebral infarction c)Gait disturbance with Knee and hip osteoarthritis d)Diabetes (HbA1c>10% or diabetic neuropathy) 6. Severe low back pain and vertebral body fracture 7. Severe systemic past history such as heart, liver or kidney disease 8. Peptic ulcer 9. Severe abnormal symptom of blood 10. Pregnant or intend to become pregnant during the study period 11. History of hypersensitivity to Limaprost, celecoxib and sulfonamide 12. Aspirin-induced asthma 13. Patients who were recognized unsuitable for this study by primary physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Zurich claudication questionnaire | — |
Secondary
| Measure | Time frame |
|---|---|
| 6-minute walk test JOA back pain evaluation questionnaire SF-36 Lumber extension test Safety: adverse events | — |
Countries
Japan
Contacts
Public ContactKoichi Hashimoto
University of Tsukuba Tsukuba Critical Path Research and Education Integrated Leading Center, Course of life-style related
Outcome results
None listed