Effect of meal on pharmacokinetics of omeprazole and rabeprazole.

Effect of meal on pharmacokinetics of omeprazole and rabeprazole. - PPI-PK

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004761

Enrollment

Registered

2011-12-21

Start date

2010-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal reflux disesae

Interventions

omeprazole at fasting, washout 1-4 week, omeprazole after meal, washout 1-4 week, rabeprazole at fasting, washout 1-4 week, rabeprazole after meal omeprazole after meal, washout 1-4 week, omeprazole

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. healthy volunteer 2. subjects with written informed consent

Exclusion criteria

Exclusion criteria: 1. Subjects with past history of drug allergy including omeprazole and rabeprazole 2. Any liver, kidney, or heart diseases 3. Past history of GI tract surgery or vagotomy 4. Any medications due to any diseases 5. Subjects required medications during the study period

Design outcomes

Primary

Measure	Time frame
AUC of omeprazole and rabeprazole after meal	—

Countries

Japan

Contacts

Public ContactTomoyuki Koike

Tohoku University Graduate School of Medicine Division of Gastroenterology

022-717-7171

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026