The long term effect of NSAIDs on travoprost induced conjunctival hyperemia and IOP reduction in normal eyes

The long term effect of NSAIDs on travoprost induced conjunctival hyperemia and IOP reduction in normal eyes - Interaction between travoprost and NSAIDs

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004760

Enrollment

Registered

2010-12-21

Start date

2010-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

normal eyes

Interventions

Control group

30 eyes of randomly selected one of two eyes. Flavin adenine dinucleotide (FAD) solution was dropped two times a day during 28 days. In the second day, at 9AM, travoprost was dropped once a day during

Contralateral 30 eyes. Bromfenac Na solution was dropped two times a day during 28 days. In the second day, at 9AM, travoprost was dropped once a day during 27 days.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Ophthalmologically normal eyes, no systemic diseases

Exclusion criteria

Exclusion criteria: 1.Treated or treating ocular or systemic diseases 2.Past history of ocular surgery 3.Allergy for NSAIDs or PG-related drugs 4.Wearing contact lenses during the study 5.Participation in other clinical researches within 6 months 6.Using glaucoma drugs 7.Using steroid drugs topically or systemically

Design outcomes

Primary

Measure	Time frame
IOP reduction, hyperemia, superficial punctate keratopathy (SPK)	—

Countries

Japan

Contacts

Public ContactRei Sakata

University of Tokyo, Faculty of Medicine Department of Ophthalmology

03-5800-8660

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026