Prospective study to examine whether Blood N-terminal proBNP (N-terminal pro brain natriuretic peptide) can be used as an indicator of cardiac preload during massive fluid resuscitation in critically ill patients.

Prospective study to examine whether Blood N-terminal proBNP (N-terminal pro brain natriuretic peptide) can be used as an indicator of cardiac preload during massive fluid resuscitation in critically ill patients. - Prospective study to examine blood levels of N-terminal proBNP as an indicator of cardiac preload during resusucitation.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004671

Enrollment

Registered

2010-12-13

Start date

2010-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shock

Interventions

NT-proBNP

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Mean Arterial Pressure ; under 65mmHg 2) Cardiac Index ; under 2.2L/min/m2 3) Patients who need IV fluid infusion more than 1,000mL in four hours 4) No gender restrictions 5) Adults over 20 years 6) Patients who had PiCCO catheter inserted to evaluatehemodynamic monitoring 7) Patients with the consent of himself, his legal representative or guardian

Exclusion criteria

Exclusion criteria: 1) Systemic Vascular Resistance Index ; 1200 dynesxsec/cm5/m2 2) History of heart failure 3) Patients without the consent of himself, his legal representative or guardian

Design outcomes

Primary

Measure	Time frame
To evaluate the correlation between the NT-proBNP level and global end-diastolic volume index (GEDVI) measured by thermodilution method	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026