The prophylactic effect of continuously infused landiolol started just before the end of surgery against tachycardia during tracheal extubation

The prophylactic effect of continuously infused landiolol started just before the end of surgery against tachycardia during tracheal extubation - The prophylactic effect of landiolol against tachycardia during tracheal extubation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004648

Enrollment

Registered

2010-12-01

Start date

2010-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing a surgery with general anesthesia

Interventions

20 gamma group: Continuous infusion of landiolol (20 micro g/kg/min)is started about 10 min before the end of surgery and finished just after tracheal extubation. 10 gamma group: Continuous infusion o

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing surgery under general anesthesia with tracheal intubation

Exclusion criteria

Exclusion criteria: patients with chronic heart failure, atrio-ventricular block, sick-sinus syndrome, diabetic ketoacidosis, hypothyroidism, WPW syndrome, hypotention (systric and diastric blood pressure should be more than 90 and 60, respectively), bradycardia (HR < 50), recieved nicardipine treatment for hypertention with extubation, asthma, with beta-blocker treatment, with anaphylaxis for flurbiprofen, with pregnancy, with anaphylaxis for landiolol, judged as unsuitable for this study

Design outcomes

Primary

Measure	Time frame
the maximum heart rate during tracheal extubation	—

Secondary

Measure	Time frame
age, height, body weight, sex, preoperative complications blood pressure and heart rate (at starting infusion of landiolol, 10 min after starting infusion of landiolol, maximum heart rate during tracheal extubation, after tracheal extubation, at discharging the patient from operating room) operative time, anesthetic time, total fluid infusion, total operative bleeding, total volume of urine, total transfusion total dose of fentanyl, total dose of remifentanil, total dose of landiolol the incidence of side effect (bradycardia etc.)	—

Measure

Time frame

age, height, body weight, sex, preoperative complications blood pressure and heart rate (at starting infusion of landiolol, 10 min after starting infusion of landiolol, maximum heart rate during tracheal extubation, after tracheal extubation, at discharging the patient from operating room) operative time, anesthetic time, total fluid infusion, total operative bleeding, total volume of urine, total transfusion total dose of fentanyl, total dose of remifentanil, total dose of landiolol the incidence of side effect (bradycardia etc.)

—

Countries

Japan

Contacts

Public ContactToshinori Horiuchi

Bellland General Hospital Department of Anesthesia

t_horiuchi@seichokai.or.jp0722342001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026