To compare the difference of vascular calcification between lanthanum carbonate and calcium carbonate administered group in hemodialysis patients with diabetes mellitus
Conditions
Interventions
Lanthanum carbonate treatment for 1 year
Calcium carbonate treatment for 1 year
Sponsors
Nippon Kokan Fukuyama Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: -Hemodialysis patients with diabetes mellitus (good glycemic controlled patients) -Patients under good control on maintenance hemodialysis (dialysis period: less than 5 years) -Patients treated with phosphate binder for problems related to hyperphosphatemia -Patients signed informed consent document
Exclusion criteria
Exclusion criteria: -Patients with poor glycemic control -Patients with severe vascular complication -Patients who meet the contraindication criteria in package insert of lanthanum carbonate or calcium carbonate -Pregnant or possibly pregnant patients, patients on lactation -Inappropriate patients for this study according to the investigator's judgement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Abdominal aortic calcification | — |
Secondary
| Measure | Time frame |
|---|---|
| -Serum phosphate,calcium and intact-PTH -Bone metabolism markers (osteocalcin and bone alkaline phosphatase) -Bone density -Calcification evaluated by PWV,IMT and parathyroid ultrasonography -Nutritional assessment -Dose of vitamin D | — |
Countries
Japan
Contacts
Public ContactKentaro Wada
Nippon Kokan Fukuyama Hospital Division of Nephrology and Dialysis, Department of Internal Medicine
Outcome results
None listed