The investigation of treatment for major depression compared monotherapy of mirtazapine, sertraline or duloxetine with combination therapy of mirtazapine and sertraline, or mirtazapine and duloxetine

The investigation of treatment for major depression compared monotherapy of mirtazapine, sertraline or duloxetine with combination therapy of mirtazapine and sertraline, or mirtazapine and duloxetine - The investigation of treatment for major depression compared monotherapy of mirtazapine, sertraline or duloxetine with combination therapy of mirtazapine and sertraline, or mirtazapine and duloxetine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004567

Enrollment

500

Registered

2011-04-01

Start date

2010-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depression

Interventions

Drug: mirtazapine Period: 6 months Dose: dose according to drug information Drug: sertraline Period: 6 months Dose: dose according to drug information Drug: duloxetine Period: 6 months Dose: dos

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients that the total poit of teh item (No.1-17) of the Hamilton's deressive scale are more than 18 point.

Exclusion criteria

Exclusion criteria: The patints with a heavy suicide idea The patints wuth severe physical diseases

Design outcomes

Primary

Measure	Time frame
Hamilton's Rating Scale for Depression SF-36 Pittsburgh Sleep Quality Index Clinical Global Impression The UKU side effect rating scale	—

Secondary

Measure	Time frame
Antidepressants side effect interview sheet (St. Marianna University School of Medicine version)	—

Countries

Japan

Contacts

Public ContactKenichi Osada

St. Marianna University School of Medicine Neuropsychiatry

k2osada@marianna-u.ac.jp

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026