Natural history of vertebral artery dissection presented with non-hemorrhagic and non-ischemic sympotoms

Natural history of vertebral artery dissection presented with non-hemorrhagic and non-ischemic sympotoms - Natural history of vertebral artery dissection (VAD study)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000004557

Enrollment

Registered

2010-11-15

Start date

2010-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vertebral artery dissection

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) First inclusion criteria: Those who meet all the following criteria (A)-(C) are included. (A) Those who meet (a), (b) and (c), or only (d) (a) Presence of headache and/or neck pain. Laterality and characteristics of the pain are not considered (b) Sudden onset (c) Disturbance in daily living such as work, housework or school attendance, at least temporarily (d) Admission by an ambulance car with complaint of acute headache and/or neck pain (B) Within 24 hours after the onset (C) Age between 20 and 80 years old. (D) Informed consent available. (2) Second inclusion criteria (A) Vertebral artery dissection in MRI/MRA studies within 4 hours after initial presentation (B) No subarachnoid hemorrhage or cerebral infarction associated with this presentation

Exclusion criteria

Exclusion criteria: (a) One or more points in modified National Institutes of Health Stroke Scale (NIHSS) (b) Subarachnoid hemorrhage, intracerebral hematoma or cerebral infarction (c) Under antithrombotic treatment (d) Previous open surgery or endovascular therapy for the posterior fossa or the neck (e) Contraindication for magnetic resonance imaging

Design outcomes

Primary

Measure	Time frame
Percentage of the patients resulting in subarachnoid hemorrhage, cerebral infarction or radiographic progression within 6 months after inclusion, among those who initially presented with pain (headache or neck pain) as the only symptom of vertebral artery dissection	—

Secondary

Measure	Time frame
1. Percentage of the vertebral artery dissection among those who present with acute headache or neck pain 2. Percentage of the onset of subarachnoid hemorrhage, cerebral infarction or radiographic progression within 6 months after inclusion 3. Percentage of the patients without any radiographical changes within 6 months after inclusion 4. Percentage of the patients with radiographical improvement within 6 months after inclusion 5. Modified Rankin scale of the patients 6 months after inclusion	—

Measure

Time frame

1. Percentage of the vertebral artery dissection among those who present with acute headache or neck pain 2. Percentage of the onset of subarachnoid hemorrhage, cerebral infarction or radiographic progression within 6 months after inclusion 3. Percentage of the patients without any radiographical changes within 6 months after inclusion 4. Percentage of the patients with radiographical improvement within 6 months after inclusion 5. Modified Rankin scale of the patients 6 months after inclusion

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Countries

Japan

Contacts

Public ContactHidenori Endo

Kohnan hospital Neurosurgery

hideendo@gmail.com022-248-2131

Outcome results