Recent-onset atrial fibrillation
Conditions
Interventions
Oral loading of propafenon, 150 mg q.d.
Oral loading of flecainide,100 mg q.d.
Sponsors
Fujita Health University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria were an age of 18 to 75 years, an episode of electrocardiographically documented atrial fibrillation of recent onset (less than 48 hours earlier), a mean heart rate of more than 70 beats per minute, and a systolic pressure of 100 mmHg or more.
Exclusion criteria
Exclusion criteria: Patients were excluded if they had one or more of the following findings: electrocardiographic evidence of ventricular pre-excitation or bundlebranch block (QRS interval >120 msec), a previous episode of atrial fibrillation lasting seven days or more, ischemic heart disease, dilated or hypertrophic cardiomyopathy, a history of heart failure, severe valvular heart disease, chronic cor pulmonale, left ventricular dysfunction (ejection fraction, 50 percent), a long QT interval or the Brugada syndrome, the bradycardia-tachycardia syndrome (resting heart rate, 50 beats per minute, or repetitive sinoatrial blocks during waking hours), documentation of previous episodes of second or third-degree atrioventricular block, previous thromboembolic episodes, acute disease, very severe chronic diseases (e.g., muscular dystrophies or systemic collagen diseases), renal or hepatic insufficiency, previous hypokalemia (potassium level, <3 mmol per liter), suspected or known pregnancy, a known intolerance of flecainide or current propafenone, or current prophylactic antiarrhythmic treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Termination of atrial fibrillation within 120 min after treatment of propafenone or flecainide | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety (blood pressure and proarrhythmia) Plasma drug concentration | — |
Countries
Japan
Contacts
Public ContactEiichi Watanabe
Fujita Health University School of Medicine Department of Cardiology
Outcome results
None listed