coronary heart disease
Conditions
Interventions
1. Experimental A capsule of omega-3 Polyunsaturated Fatty Acid, 300mg (including 15% docosahexaenoic acid, 40% eicosapentaenoic acid and other), 12 capsules per day in 12 week.
2. Placebo A capsu
Sponsors
Kanazawa University
Toyama University, Kurume University, Kanazawa University, Disaster Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 20 - 39 years old 2. A native Japanese speaking ability 3. Physical and metal status to possible understands scope and contents in the trial and gets informed consent
Exclusion criteria
Exclusion criteria: 1. Heavy drinker 2. Heavy smoker (over 40 cigarettes per day) 3. Habit of eating fish over 4 times per week 4. Use of polyunsaturated fatty acid supplement within 3 month at regular intervals 5. Current suspicion in coronary heart disease, hypertension (resting blood pressure greater than 160/100 mmHg), diabetes and pregnancy 6. Use of anti-epilepsy drug, lithium, ethyl icosapentate and anti-coagulant drug (for example, aspirin, warfarin, etc) within 3 month at regular intervals 7. History and current suspicion in diagnosis of psychosis, bipolar I disorder, alcoholic, substance-related disorder and eating disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate and blood pressure [before and after 12 weeks supplementation] | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cardiovascular indices [before and after 12 weeks supplementation] - Cardiac output - Stroke volume - Total peripheral resistance - Pre-ejection period - Normalized pulse volume - Baroreceptor reflex sensitivity - Arterial stiffness 2. Neuroendocrinological indices [before and after 12 weeks supplementation] - Salivary cortisol - Salivary MHPG 3. Neuroimmunological index [before and after 12 weeks supplementation] - Salivary Ig-A 4. Subjective ratings [before and after 12 weeks supplementation] - Subjective ratings to stressful tasks 5. Behavioral indices [before and after 12 weeks supplementation] - Task performance - Recall performance of Cahill's script 6. Psychological indices [before and after 12 weeks supplementation] - Buss-Perry Aggression Questionnaire, - Behavioral Inhibition/Activation System Scale - Short-Form Eysenck Personality Questionnarie-Revised - Lee's Type Scale 2nd version (love attitude scale) - State-Trait Anxiety Inventory 7. Blood [before and after 12 weeks supplementation] - Omega-3 and -6 concentrations in red blood cells | — |
Countries
Japan
Contacts
Public ContactKenta Matsumura
College of Science and Engineering, Kanazawa University School of Mechanical Engineering
Outcome results
None listed