Systemic/cutaneous lupus erythematosus Sjogren'
Conditions
Interventions
Hydroxychloroquine 200 mg will be administrated once daily. If insufficient, dosage can be escalated to 400 mg twice daily, but not exceed 6.5 mg/kg/day.
Sponsors
Kanazawa University Graduate School of Medical Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with systemic/cutaneous lupus erythematosus or Sjogren's syndrome who have annular erythema on the face and/or trunk that are resistant to steroid and/or tacrolimus treatment for external use. 2. Patients without retinopathy examined by ophthalmologist.
Exclusion criteria
Exclusion criteria: 1. Patients with current or previous history of retinopathy. 2. Patients unable to take or unsupplied with 4-aminoquinoline. 3. Body weight is less than 30 Kg. 4. History of pregnancy or lactation. 5. Other patients who were judged to be ineligible for the study by an attending physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of size and/or color of erythematous lesion Patient satisfaction assessed by visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment for safety | — |
Countries
Japan
Contacts
Public ContactKazuhiko Takehara
Kanazawa University Graduate School of Medical Science Department of Dermatology
Outcome results
None listed