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The impact of dipeptidyl peptidase-4 inhibitor on coronary microvascular function in patients with type2 diabetes mellitus

The impact of dipeptidyl peptidase-4 inhibitor on coronary microvascular function in patients with type2 diabetes mellitus - The impact of dipeptidyl peptidase-4 inhibitor on coronary microvascular function in patients with type2 diabetes mellitus

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000004390
Enrollment
40
Registered
2010-11-01
Start date
2010-11-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetic patients with stable angina pectoris who undergo percutaneous coronary intervention

Interventions

DPP-4 inhibitor tretment 1 year after measurement of baseline IMR value no treatment

Sponsors

Cardiovascular Division, Hyogo College of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Stable angina pectoris 2) Type2 diabetes mellitus who are controlled well 3) Culprit lesion involving 75% or more of the stenosis without LAD 4) Successful revascularization of target lesion 5) Patients providing written consent for participattion in this clinical trial on their own volition after receiving a thorough explanation of the study

Exclusion criteria

Exclusion criteria: 1) Target lesion is left main coronary artery 2) Patients on hemodialysis 3) Patients with acute coronary syndorome 4) Patients with contraindication of antiplatelet or anticoagulation drug 5) Patients who are uncontrolled diabetes mellitus 6) Patients who are judged by the principal investigator to be ineligible for enrollment in the study

Design outcomes

Primary

MeasureTime frame
Change in index of microcirculatory index

Secondary

MeasureTime frame
Absolute and percent changes of high-sensitive CRP and adiponectine

Countries

Japan

Contacts

Public ContactMasashi Fukunaga

Hyogo College of Medicine Cardiovascular Division

0798-45-6553

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026