Effect of a mouthwash with caffeine on oral bacterial species in healthy subjects

Effect of a mouthwash with caffeine on oral bacterial species in healthy subjects - Effect of caffeine on oral bacterial species

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004379

Enrollment

Registered

2010-10-18

Start date

2010-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aspiration pneumoniae

Interventions

Mouth washes with Caffeine solution every day for 4-weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The persons who are healthy

Exclusion criteria

Exclusion criteria: 1) The persons who have swallowing problem 2) The persons who have mouth disease 3) The persons who have gastric ulcer (medical record) 4) The persons who have heart disease, 5) The persons who have glaucoma 6) The persons who take psychotropic drug 7) The persons who take antibiotic 8) Pregnant women, parturient women, nursing women 9) The persons who take caffeine in excess 10) The persons who are sensitive to bitter taste 11) The persons who need the legal representative

Design outcomes

Primary

Measure	Time frame
Change of oral microbiota at 2, 4 weeks after	—

Secondary

Measure	Time frame
Change of oral microbiota at 6 weeks after	—

Countries

Japan

Contacts

Public ContactKatumasa Ookawa

Industrial Research Institute of Shizuoka Prefecture Planning Coordination Department

ookawa@iri.pref.shizuoka.jp054-278-3028

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026