A multi-institutional study evaluating the effects of laxatives and antiemetics for prevention of opioid-induced adverse events -J-RIGID study-

A multi-institutional study evaluating the effects of laxatives and antiemetics for prevention of opioid-induced adverse events -J-RIGID study- - J-RIGID study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000004348

Enrollment

1000

Registered

2011-06-01

Start date

2010-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer pain

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Cancer patients to whom oral formulation of strong opioid analgesic was newly prescribed

Exclusion criteria

Exclusion criteria: *Patients who received radiotherapy or chemotherapy during 10 days before start of ingestion of opioid analgesics or during study period *Patients who received surgical operation during 7 days before start of ingestion of opioid analgesics or during study period *Patients who took antiemetics or laxatives due to other reasons than prevention of opioid-induced gastrointestinal dysfunction *Patients who had diarrhea or constipation before ingestion of opioid analgesics *Patients who had nausea or vomiting due to organic dysfunction including brain tumor *Patients whose performance status was 3 or 4

Design outcomes

Primary

Measure	Time frame
Incidence of opioid-induced constipation, nausea and vomiting	—

Secondary

Measure	Time frame
Prevalence of premedication, Choice of laxatives and antiemetics	—

Countries

Japan

Contacts

Public ContactYoshinori Itoh

Gifu University Hospital Pharmacy

yositou@gifu-u.ac.jp058-230-7080

Outcome results