Simple febrile seizure
Conditions
Interventions
Single dose of diazepam 0.5mg/kg
Two sequential doses of diazepam 0.5mg/kg with eight hours interval
diazepam 0.3mg/kg/dose 3 times a day during febrile period (terminated after confirmation that feve
Sponsors
Tokyo Metropolitan Pediatric acute disease clinical research network
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. single 15 minutes or less generalized seizure episode within 72 hours 2. no prior use of anticonvulsant within 72 hours 3.body temperature >= 38.0 degree Celsius at visiting 4. six months to five years old. 5. alert conscious status with spontaneous eye opening and crying or spontaneous speech, and moves spontaneously or purposefully without the paralysis 6. no more than single history of afebrile seizures 7. absence of neurological disorder(include mental retardation and developmental disorder), malformation syndrome, dysmetabolic syndrome and electrolyte abnormality. 8. written consent from the parents
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of patients occurring febrile seizures after registration. | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse events frequency and duration prevalence of CNS infection, neurological disease and metabolic disease | — |
Countries
Japan
Contacts
Public ContactYoshihiko Morikawa
Tokyo Metropolitan Children's Medical Center Department of Clinical Research
Outcome results
None listed