Theta-burst transcranial magnetic stimulation in the treatment of depression: A double-blind, randomized, placebo-controlled crossover trial

Theta-burst transcranial magnetic stimulation in the treatment of depression: A double-blind, randomized, placebo-controlled crossover trial - Theta-burst transcranial magnetic stimulation in the treatment of depression: A double-blind, randomized, placebo-controlled crossover trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004277

Enrollment

Registered

2010-10-01

Start date

2010-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder

Interventions

iTBS or cTBS will be applied in the left and right prefrontal cortex. Sham (1 week), Washout (3 weeks), Left TBS (1 week), Washout (3 weeks), Right TBS (1 week) Left TBS (1 week), Washout (3 weeks),

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Patients with DSM-IV-TR of major depressive disorder 2)Patients scored greater than 18 on the HAMD 3)Patients have failed a minimum of 1 course of antidepressant medication in the current depressive episode

Exclusion criteria

Exclusion criteria: 1)Severe suicidal idea 2)Neurological disorders/organic brain disorders 3)History of convulsive disorders 4)Drug or alcohol abuse/dependence 5)Implanted electronic devices/magnetic material 6)Severe physical diseases

Design outcomes

Primary

Measure	Time frame
HAMD, MADRS, and CGI at baseline, week 1, week 2, week 3, and week 4	—

Countries

Japan

Contacts

Public ContactShinsuke Kito

Kyorin University School of Medicine Department of Neuropsychiatry

psychiat@ks.kyorin-u.ac.jp0422-47-5511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026