Preventing postoperative pain: Effect of Neurokinin-1 receptor antagonist

Preventing postoperative pain: Effect of Neurokinin-1 receptor antagonist - Preventing postoperative pain: Effect of Neurokinin-1 receptor antagonist

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004232

Enrollment

Registered

2010-09-18

Start date

2010-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

Patients received abdominal surgery of gynaecology are randomly assigned aprepitant group to Control group. On the day of surgery, aprepitant group takes orally Aprepitant (125mg) at 2 hours before in

40 mg) at 2 hours before induction of anesthesia.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients are 20-65 years old who met the criteria of the American Society of Anesthesiologists physical status of 1-2 and undergo abdominal surgery. Having written informed consent.

Exclusion criteria

Exclusion criteria: Patiens are excluded the criteria of the American Society of Anesthesiologists physical status of over 3 and have the history of hypersensitivity for aprepitant.

Design outcomes

Primary

Measure	Time frame
postoperative pain and morphine consumption	—

Secondary

Measure	Time frame
frequency of the PONV and pruritus	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026