Cerebral inferction
Conditions
Interventions
Aspirin treatment group
Aspirin 81 to 100 mg QD Duration of treatment
1 year
Cilostazol treatment group
Cilostazol 200mg BID In addition, it fluctuates suitably according to age and conditions. Duration of treatment
Sponsors
Nakamura Memorial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with modified Rankin scale 0,1,or 2. Patients aged 80 and below years at time of consent. CT, MRI imaging: Patients with the extensive cerebral infarction dominated by a single vessel, and with passed over time when the infarct area is enhanced with CT or MRI imaging. Vascular imaging: Patients with occlusion or severe stenosis of IC or MCA(excluding target of CEA). Patient with stable general status. Inclusion criteria of cerebral blood flows at rest and cerebrovascular reserve capacities A. Patients with 80% and more of CBF at rest, and 30% and less of cerebrovascular reserve. capacities B. Patients with 80% and less of CBF at rest, and 10 to 30% of cerebrovascular reserve capacities.
Exclusion criteria
Exclusion criteria: Patients by whom bypass surgery, CEA, or intravascular treatments are planned Patients with cerebral infarction caused by non-arteriosclerosis. Patients with critical complications such as malignant neoplasm, hepatic cirrhosis, renal failure, respiratory failure. Patients with myocardial infarction for less than six months. Patients with 300 or more mg/dl of fasting plasma glucose levels, or insulin treatment. Patients with 110 or more mmHg of diastolic blood pressure. Patients with artery to artery embolism. Patients with cardiogenic cerebral embolism. Patients with hemorrhage or bleeding tendency (hemophilia, capillary fragility, intracranial hemorrhage, hemorrhage in the digestive tract, hemorrhage in the urinary tract, hemoptysis, and hemorrhage in the vitreous body) Patients with ischemic heart failure Patients with a history of hypersensitivity to salicylic acid formulations or ingredients of cilostazol tablets Patients with aspirin asthma (asthma attacks induced by nonsteroidal antiinflammatory analgesic agents) or a history of aspirin asthma Pregnant, possibly pregnant, or nursing women Patients who are otherwise judged inappropriate for inclusion in the study by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of cerebral blood flows at rest and cerebrovascular reserve capacities using the dual-table ARG method | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. cardiovascular events (Stroke,MI,PAD etc.) 2.ADL score (m-RS, Barthel index) 3. Existence of the onset of pneumonia | — |
Countries
Japan
Contacts
Public ContactKenji Kamiyama
Nakamura Memorial Hospital Department of Neurosurgery
Outcome results
None listed