Effects of itraconazole, riphampicin and grapefruit juice on the pharmacokinetics and pharmacodynamics of nadolol in healthy volunteers

Effects of itraconazole, riphampicin and grapefruit juice on the pharmacokinetics and pharmacodynamics of nadolol in healthy volunteers - Nadolol-drug interaction study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004221

Enrollment

Registered

2010-10-01

Start date

2010-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

Subjects receive orally a single dose of nadolol (30 mg) with itraconazole (100 mg) and water. Subjects receive orally a single dose of nadolol (30 mg) with grapefruit juice (300 mL). Subjects take

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults

Exclusion criteria

Exclusion criteria: Smoker

Design outcomes

Primary

Measure	Time frame
Nadolol pharmacokinetics Blood pressure and heart rate	—

Countries

Japan

Contacts

Public ContactShingen Misaka

Fukushima Medical University Department of Pharmacology

misaka@fmu.ac.jp024-547-1153

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026