Efficacy of beta-blocker on the autonomic nervous activities and the onset of atrial fibrillation or flutter in patients after cardiac surgery.

Efficacy of beta-blocker on the autonomic nervous activities and the onset of atrial fibrillation or flutter in patients after cardiac surgery. - Impact of beta-blocker on autonomic nervous activities and onset of atrial fibrillation/flutter following cardiac surgery.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004216

Enrollment

Registered

2010-10-01

Start date

2009-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial fibrillation or flutter following cardiac surgery

Interventions

Intravenous landiolol hydrochloride administration (5 mirogram/Kg/min, given immediately after cardiac surgery up to 2 days after initiation of administration of carvedilol) Oral carvedilol administ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing cardiac surgery

Exclusion criteria

Exclusion criteria: 1. Patients with chronic or paroxysmal atrial fibrillation 2. Patients receiving antiarrhythmic agents: Ia, IIc and IV groups 3. Patients with sick sinus syndrome 4. Patients with higher than 2 degree atrioventricular block 5. Heart failure patients with EF less than 30% 6. Patients with bronchial asthma 7. Patients receiving beta blockers

Design outcomes

Primary

Measure	Time frame
This study is a randomized open-label controlled trial. An ultra-short acting beta- blocker (landiolol hydrochloride) is intravenously given immediately after cardiac surgery, followed by oral carvedilol in the patients randomized to treatment group. The incidence of postoperative atrial fibrillation / flutter during 7days after operation is evaluated as a major outcome.	—

Secondary

Measure	Time frame
The autonomic changes are evaluated by the analysis of heart rate variability (Holter recording analysis) as secondary outcomes.	—

Countries

Japan

Contacts

Public ContactKazuma Kanetsuki

Shimane University Faculty of Medicine Department of Cardiovascular and Thoracic Surgery

kkazuma@med.shimane-u.ac.jp0853202223

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026