A prospective, randomized controlled trial comparing alendronate and alendronate plus alphacalcidol therapy in patients with steroid-induced osteoporosis accompanied with interstitial pneumonias

A prospective, randomized controlled trial comparing alendronate and alendronate plus alphacalcidol therapy in patients with steroid-induced osteoporosis accompanied with interstitial pneumonias - Steroid-induced osteoporosis accompanied with interstitial pneumonias

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004188

Enrollment

Registered

2010-09-10

Start date

2006-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

interstitial pneumonias

Interventions

alendronate alendronate plus alphacalcidol

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The patients who was expected to treat with oral prednisolone 30mg/day at least for a week and continued with 5mg/day of prednisolone at least for three months for the therapy of interstitial pneumonias

Exclusion criteria

Exclusion criteria: (1) The patients who have severe complications (2) The patients who have the diseases of bone metabolism (3) The patients who were administered steroid therapy within a year (4) The patients who are administered therapy affecting bone metabolism (5) The patients who have fracture or scoliosis at 3rd to 5th lumbar (6) The patients who have impaired renal function (Cr > 1.5mg/dl) (7) The patients who are contraindicated to take alendronate or alphacalcidol (8) The patients who are pregnant (9) The patients who attended clinical trials within three months

Design outcomes

Primary

Measure	Time frame
(1) The change in the lumbar-spine bone mineral density from baseline (2) The change in the markers of of bone metabolism from baseline	—

Countries

Japan

Contacts

Public ContactNoriho Sakamoto

Nagasaki University Hospital Second Department of Internal Medicine

nsakamot@nagasaki-u.ac.jp0958197273

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026