Effect of Pitavastatin on preventing ischemic complications with carotid artery stenting (EPOCH-CAS)

Effect of Pitavastatin on preventing ischemic complications with carotid artery stenting (EPOCH-CAS) - Effect of Pitavastatin on preventing ischemic complications with carotid artery stenting (EPOCH-CAS)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000004113

Enrollment

100

Registered

2010-08-27

Start date

2010-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with carotid artery stenosis scheduled to undergo carotid artery stenting

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients who have carotid artery stenosis and are scheduled to undergo carotid artery stenting more than 4 weeks after enrollment 1. Patients with 50% >= symptomatic stenosis or 80% >= asymptomatic carotid stenosis using the NASCET criterion 2. Patients at high risk for CEA 3. Patients requiring revascularization using CAS 2) Patients with 20 years old or older at the time of provision of consent 3) Patients providing written informed consent for participation in this clinical trial on their own volition after receiving a thorough explanation about the study

Exclusion criteria

Exclusion criteria: 1) Patients with a history of hypersensitivity to any of the components of LIVALO tablet 2) Patients taking cyclosporin 3) Pregnant and possibly pregnant women, breast feeding women 4) Patients taking statins 5) Patients with liver dysfunction (AST or ALT &#8805; 100IU)&#61481; or biliary obstruction 6) Patients with severe renal dysfunction 7) Patients with contraindications for MRI 8) Patients who are judged by the principal or other investigator to be ineligible for enrollment in the study

Design outcomes

Primary

Measure	Time frame
Evaluation of distal embolism using MRI DWI	—

Secondary

Measure	Time frame
1) The composition and volume change of carotid artery plaque using MRI plaque imaging 2) The property change of carotid artery plaque using B-mode echo (GSM) 3) The incidence of ischemic stroke on the ipsilateral side of the carotid artery stenting in 4 weeks after CAS 4) The change of the serum lipid marker (total cholesterol, HDL cholesterol, triglycerides and LDL cholesterol) 5) The change of serum high sensitivity CRP 6) Cardiovascular events and mortality	—

Measure

Time frame

1) The composition and volume change of carotid artery plaque using MRI plaque imaging 2) The property change of carotid artery plaque using B-mode echo (GSM) 3) The incidence of ischemic stroke on the ipsilateral side of the carotid artery stenting in 4 weeks after CAS 4) The change of the serum lipid marker (total cholesterol, HDL cholesterol, triglycerides and LDL cholesterol) 5) The change of serum high sensitivity CRP 6) Cardiovascular events and mortality

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Countries

Japan

Contacts

Public ContactNaoki Toma

Mie university school of medicine Department of neurosurgery

ntoma@clin.medic.mie-u.ac.jp059-232-1111

Outcome results