Examination regarding hypothalamus-pituitary-adrenal axis activity in mood disorder and post-traumatic stress disorder (PTSD) as determined by Dexamethasone/corticotropin releasing hormone (DEX/CRH) test

Examination regarding hypothalamus-pituitary-adrenal axis activity in mood disorder and post-traumatic stress disorder (PTSD) as determined by Dexamethasone/corticotropin releasing hormone (DEX/CRH) test - Dexamethasone/corticotropin releasing hormone test in mood disorder and post-traumatic stress disorder

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000004082

Enrollment

300

Registered

2010-08-22

Start date

2013-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mood disorder, post-traumatic stress disorder

Interventions

Dexamethasone 1mg tablet and iv corticotropin releasing hormone (100ug) Dexamethasone 1.5mg tablet and iv corticotropin releasing hormone (100ug)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The following inclusion criteria is used: mood disorders (i.e., unipolar or bipolar), post-traumatic stress disorder, and healthy volunteers. To assess the subjects with past or current major mental disorders or personality disorders, the Structured Clinical Interview for DSM-IV Axis I Disorders are used

Exclusion criteria

Exclusion criteria: The following exclusion criteria is used: a history of a neurological illness, chronic alcoholism, or substance abuse

Design outcomes

Primary

Measure	Time frame
Association between psychological measurement and plasma cortisol concentration after dexamethasone oral administration and CRH infusion.	—

Countries

Japan

Contacts

Public ContactKosuke Narita

Gunma University Graduate School of Medicine Department of Psychiatry and Neuroscience

knarita@med.gunma-u.ac.jp+81272208185

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026