Hypertension patients with left ventricular diastolic dysfunction
Conditions
Interventions
ARB/HCTZ
ARB/CCB
Sponsors
Diastolic Dysfunction Study Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Hypertension patients are those who have been treated with anti hypertensive therapy including ARB usual dose and whose blood pressure has not been sufficinetly controlled Left ventricular diastolic dysfunction patients LVEF >=50% e'<8cm/s and or E/e' >=15 Outpatiens Obtaining written informed consent
Exclusion criteria
Exclusion criteria: Insufficiently controlled hypertension DBP more than 110mmHg Secondary hypertension Diabetes mellitus patient under insulin treatment Onset of myocardial infarction or stroke within 6 months before recruiting Concurrent hepatic dysfunction GPT more than 3 times the upper limit of normal values Renal dysfunction sCr more than 2.0 mg/dL Gout or hyperuricemia uric acid more than 8.0 mg/dL Heart failure with NYHA 3 or more AF undergo echocardiography Valvular disease Malignant tumor and/or poor prognosis severe disease Women who are pregnant, enable to be pregnant, or are breastfeeding Concurrent treatment with diuretics and/or CCB Hypersensitivity or allergy to losartan, HCTZ and amlodipine Hypersensitivity or allergy to thiazide and other analogs Patients who are determined by the investigators to be unsuitable
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in e' and e'/E | — |
Countries
Japan
Outcome results
None listed