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Maintenance of baroreflex sensitivity during intravenous sedation with a combination of propofol and midazolam

Maintenance of baroreflex sensitivity during intravenous sedation with a combination of propofol and midazolam - Baroreflex sensitivity during intravenous sedation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000004058
Enrollment
12
Registered
2010-08-25
Start date
2010-08-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mentally handicapped patient dental phobia

Interventions

We also analyzed the effect of intravenous sedation with a combination of propofol and midazolam during dental treatment of a group of mentally handicapped adult patients to evaluate the maintenance o

Sponsors

Matsumoto Dental University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Only patients scheduled for dental treatment under intravenous sedative were recruited for this study. Written informed consent from parents or legal guardians was obtained following careful explanation of the study's procedure, risk, and benefits. This study was performed according to guidelines set by the Declaration of Helsinki and was approved by the Institutional Review Board on Human Experiments of Matsumoto Dental University.

Exclusion criteria

Exclusion criteria: Patients with serious circulatory or respiratory diseases, epilepsy, egg or buckwheat allergies, or any other serious chronic diseases were excluded from experiments.

Design outcomes

Primary

MeasureTime frame
For analysis of spontaneous baroreflex sensitivity, we examined continuous finger arterial pressure and electrocardiograms to detect sequence changes in the R-R interval with parallel changes in arterial pressure. Our software selected all of the sequences of three or more successive heart beats in which there were concordant increases or decreases in systolic blood pressure and R-R intervals. A linear regression was applied to each of the sequences, and the mean slope during each condition was assessed as baroreflex sensitivity.

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026