rheumatoid arthritis
Conditions
Interventions
Probiotics administration group: Start oral administration of 3g a day of probiotics to RA patient 3 months before TKA.
Non probiotics administration group: Continue conventional therapy without admi
Sponsors
Center for Rheumatic Diseases, Yokohama City University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients who are diagnosed with RA according to the ACR criteria 2.Patients with destructive knee joints scheduled for TKA 3.Patients who agreed not to undertake major changes of therapy for RA during the administration period
Exclusion criteria
Exclusion criteria: 1.Patients with allergy to milk or foods which contain lactobacillus 2.Patients with critical complications in heart, kidney, liver, and blood disorder 3.Patients considered to be ineligible by the responsible researcher or assigned researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of hyaluronic acid (HA) in joint fluid and serum. | — |
Secondary
| Measure | Time frame |
|---|---|
| DAS28, mHAQ. The concentration of MMP-3 and TNF-alpha in joint fluid. The concentration of MMP-3 in serum. The titer of anti-E-coli antibody | — |
Countries
Japan
Contacts
Public ContactKatsushi Ishii
Yokohama City University Medical Center Center for Rheumatic Diseases
Outcome results
None listed