rheumatoid arthritis
Conditions
Interventions
Probiotics administration group: oral administration of 3g a day of probiotics to RA patient
Non probiotics administration group: Continue conventional therapy without administration of probiotics.
Sponsors
Center for Rheumatic Diseases,Yokohama City University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients who are diagnosed with RA according to the ACR criteria 2.RA patients treated with MTX 3.Patients who agreed not to undertake major changes of therapy for RA during the administration period 4.Patients at the age of 16 or older
Exclusion criteria
Exclusion criteria: 1.Patients with allergy to milk or foods which contain lactobacillus 2.Patients with critical complications in heart, kidney, liver, and blood disorder 3.Patients treated with biologics 4.Patients considered to be ineligible by the responsible researcher or assigned researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of DAS28 score before administration, and at 1, 4, 12, 24 weeks after administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of mHAQ and VAS before administration, and at 1, 4, 12, 24 weeks after administration Investigation of adverse events, clinical examination values, and the titer of anti-E-coli antibody | — |
Countries
Japan
Contacts
Public ContactKatsushi Ishii
Yokohama City University Medical Center Center for Rheumatic Diseases
Outcome results
None listed