Non-squamous non-small cell lung cancer in elderly chemo-naive patients
Conditions
Sponsors
Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Histologically or cytologically proven non-squamous non-small cell lung cancer 2)Chemo-naive clinical stage IIIB/IV or relapsed patients (no indication of surgery or radiotherapy) 3)Age of 70 years or older 4)Performance status(PS) of 0-1 in ECOG criteria 5)Adequate organ functions 6)With measurable lesion 7)Life expectancy more than 3 months 8)Written informed consent
Exclusion criteria
Exclusion criteria: 1)Patients with brain metastasis in need of steroid or anticonvulsant 2)Previous radiation therapy to primary lesion 3)History of active double cancer 4)Patients with superior vena cava syndrome 5)Uncontrollable pleural effusion, pericardial effusion or ascites 6)History of uncontrollable hypertention, diabetes mellitus, active angina pectoris, active gastrointestinal hemorrhage, recent cardiac incompetence, recent myocardial infarction, and active virus infection(except viral hepatitis) 7)Interstitial pneumonia or pulmonary fibrosis obviously detectable on chest X-ray 8)History of severe drug allergy 9)History of severe psychiatric disease 10)Patients whose participation in the trial is judged to be inappropriate by the attending doctor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival Progression free survival Safety Quality of life | — |
Countries
Japan
Contacts
Public ContactKeiko Muraki
Juntendo University, School of Medicine Department of Respiratory Medicine
Outcome results
None listed